Knee Arthritis and PRP in 2026: What Works, What Doesn’t, and Who Benefits Most

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Knee Arthritis and PRP in 2026: What Works, What Doesn’t, and Who Benefits Most

Q: How does PRP therapy differ from cortisone?

While cortisone rapidly decreases inflammation, most people feel good a few days to weeks after having the injection. However, its effects may be temporary since it does not address the cause of the problem, meaning that patients only experience temporary relief, which lasts for weeks or several months. Using cortisone may accelerate cartilage deterioration.

PRP therapy focuses on addressing the underlying cause of the issue. It does this by promoting the natural healing process through growth factors rather than addressing the symptoms. The results will be felt gradually since healing is gradual, and patients should expect to notice results between four to eight weeks after treatment.

Q: How does PRP differ from cortisone?

The mechanism behind PRP differs significantly from cortisone, which rapidly alleviates pain by suppressing inflammation. While cortisone helps reduce pain quickly, its effects are short-lived since it does not provide any solution to tissue damage. On the other hand, repeated cortisone shots may exacerbate cartilage degradation in the long run.

Unlike cortisone, PRP treatment provides a biological solution. It introduces growth factors that work by initiating and promoting the tissue regeneration process while regulating inflammation at the same time. Improvement will not be seen as quickly as in cortisone, since it typically takes four to eight weeks before PRP kicks in.

 Q: Does the injection hurt? 

Injections are typically pain-free, similar to a regular joint injection, and involve feeling pressure only at the site of injection. Our practice involves using ultrasound or fluoroscopy to guide injections to increase their efficacy while reducing pain. Post-injection, there may be some discomfort in the knee for two to four days, but it’s expected and an important part of activating the treatment.

Q: How many injections will I require?

 Patients usually undergo one to three injections that are spaced apart by four to six weeks. The number needed differs among individuals. While some may obtain relief after just one injection, others would need a full course of injections to obtain the best result.

Q: Is it okay to take ibuprofen after the procedure?

No, and this is among the most critical rules to follow. The reason is that anti-inflammatories like ibuprofen, naproxen, and aspirin prevent platelet activation, thereby compromising the effectiveness of the PRP treatment. Patients should avoid taking such medications one week prior to and up to two to four weeks following each PRP injection. However, acetaminophen can be taken as an alternative pain reliever.

Q: How do I know which provider is best?

PRP results rely heavily on your provider. You should seek the services of a board-certified doctor, preferably with expertise in interventional pain management or orthopedics. It is essential to note that PRP requires accurate and precise injections, and thus you should find a physician who can guide the procedure using imaging technology. All PRP treatments are conducted under ultrasound guidance by our board-certified doctors at Restore Spine and Pain.